{"id":1052,"date":"2019-04-14T09:04:45","date_gmt":"2019-04-14T09:04:45","guid":{"rendered":"https:\/\/albayan.edu.iq\/en\/?p=1052"},"modified":"2019-04-14T09:04:45","modified_gmt":"2019-04-14T09:04:45","slug":"intranasal-drug-delivery-of-iodohaloperidol-as-a-radiopharmaceutical-brain-imaging-agent","status":"publish","type":"post","link":"https:\/\/albayan.edu.iq\/en\/2019\/04\/14\/1052\/","title":{"rendered":"Intranasal Drug Delivery of Iodohaloperidol as a Radiopharmaceutical Brain Imaging Agent"},"content":{"rendered":"<p><span style=\"color: #ff0000;\"><strong>Assistant Prof. Dr. Ismail Taha Ibrahim<\/strong><\/span><\/p>\n<p><strong>Abstract <\/strong><\/p>\n<p>Haloperidol (HP) is a dopamine blocking agent. HP was radiolabeled with 125I using direct electrophilic substitution. Different HP formulations such as intravenous solution (VS), intranasal solution (NS) and intranasal microemulsion (NME) have been prepared. Optimum labeling yield of 125I-HP was obtained 93.42\u00b11.53%. Isopropylmyristate oil (10%), Tween 80 (30%), propylene glycol (15%) and aqueous phase (45%) were used for NME preparation. Using Swiss Albino mice, the % brain uptake were 1.4\u00b10.2, 4.3\u00b10.2 and 5.7\u00b10.4% for VS, NS and NME, respectively. 125I-HP in NME formula showed superiority as drug delivery system for brain imaging.<\/p>\n<p><strong>Keywords<\/strong>Haloperidol\u00a0\u00b7 125I\u00a0\u00b7 Chloramine-T\u00a0\u00b7 Microemulsion\u00a0\u00b7 Biodistribution\u00a0\u00b7 Brain imaging<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.researchgate.net\/publication\/329411195_Intranasal_drug_delivery_of_iodo-haloperidol_as_a_radiopharmaceutical_brain_imaging_agent\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Link to Full Article<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Assistant Prof. Dr. Ismail Taha Ibrahim Abstract Haloperidol (HP) is a dopamine blocking agent. HP was radiolabeled with 125I using direct electrophilic substitution. Different HP formulations such as intravenous solution (VS), intranasal solution (NS) and intranasal microemulsion (NME) have been prepared. Optimum labeling yield of 125I-HP was obtained 93.42\u00b11.53%. Isopropylmyristate oil (10%), Tween 80 (30%), propylene glycol (15%) and aqueous phase (45%) were used for NME preparation. Using Swiss Albino mice, the % brain uptake were 1.4\u00b10.2, 4.3\u00b10.2 and 5.7\u00b10.4% for VS, NS and NME, respectively. 125I-HP in NME formula showed superiority as drug delivery system for brain imaging. KeywordsHaloperidol\u00a0\u00b7 125I\u00a0\u00b7 <a href=\"https:\/\/albayan.edu.iq\/en\/2019\/04\/14\/1052\/\"> [&#8230;]<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[26],"tags":[27],"class_list":["post-1052","post","type-post","status-publish","format-standard","hentry","category-staff-researches","tag-staff-researches"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/paQN8v-gY","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts\/1052","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/comments?post=1052"}],"version-history":[{"count":1,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts\/1052\/revisions"}],"predecessor-version":[{"id":1053,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts\/1052\/revisions\/1053"}],"wp:attachment":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/media?parent=1052"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/categories?post=1052"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/tags?post=1052"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}