{"id":1054,"date":"2019-04-14T09:06:29","date_gmt":"2019-04-14T09:06:29","guid":{"rendered":"https:\/\/albayan.edu.iq\/en\/?p=1054"},"modified":"2019-04-14T09:06:29","modified_gmt":"2019-04-14T09:06:29","slug":"preclinical-evaluation-of-radioiodinated-quinoxaline-derivative-as-a-possible-brain-imaging-agent","status":"publish","type":"post","link":"https:\/\/albayan.edu.iq\/en\/2019\/04\/14\/1054\/","title":{"rendered":"Preclinical Evaluation of Radioiodinated Quinoxaline Derivative as a Possible Brain Imaging Agent"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"color: #ff0000;\"><strong>Assistant Prof. Dr. Ismail Taha Ibrahim<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><strong>Abstract<\/strong><\/p>\n<p style=\"text-align: justify;\">4-{(4-Methylphenyl)glycyl}-3,4-dihydroquinoxalin-2(1H)-one (QIN) was prepared from 4-(2-chloroacetyl)- 3,4-dihydroquinoxalin-1(1H)-one). \u00b9\u00b2\u2075I-QIN was prepared by electrophilic substitution using Chloramine- T as an oxidizing agent. The highest labeling yield, 94%, was obtained under the following conditions: pH 7, 15 min, 100 \u03bcg of QIN, 50 \u03bcg of Chloramine-T, and carrier-free Na\u00b9\u00b2\u2075I. The labeled compound was stable for up to 12 h post labeling. A biodistribution study of \u00b9\u00b2\u2075I-QIN in mice showed that its brain uptake was about 5.1% at 30 min post injection and remained on this level up to 1 h. As compared to commercially used radiopharmaceuticals for brain imaging, \u00b9\u00b2\u2075I-QIN is more stable and shows higher brain uptake.<\/p>\n<p style=\"text-align: justify;\"><strong>Keywords:<\/strong>quinoxaline derivatives, iodine-125, radiochemical yield, imaging, brain.<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.researchgate.net\/publication\/329918897_Preclinical_Evaluation_of_Radioiodinated_Quinoxaline_Derivative_as_a_Possible_Brain_Imaging_Agent\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Link to Full Article<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Assistant Prof. Dr. Ismail Taha Ibrahim Abstract 4-{(4-Methylphenyl)glycyl}-3,4-dihydroquinoxalin-2(1H)-one (QIN) was prepared from 4-(2-chloroacetyl)- 3,4-dihydroquinoxalin-1(1H)-one). \u00b9\u00b2\u2075I-QIN was prepared by electrophilic substitution using Chloramine- T as an oxidizing agent. The highest labeling yield, 94%, was obtained under the following conditions: pH 7, 15 min, 100 \u03bcg of QIN, 50 \u03bcg of Chloramine-T, and carrier-free Na\u00b9\u00b2\u2075I. The labeled compound was stable for up to 12 h post labeling. A biodistribution study of \u00b9\u00b2\u2075I-QIN in mice showed that its brain uptake was about 5.1% at 30 min post injection and remained on this level up to 1 h. As compared to commercially used radiopharmaceuticals for <a href=\"https:\/\/albayan.edu.iq\/en\/2019\/04\/14\/1054\/\"> [&#8230;]<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[26],"tags":[27],"class_list":["post-1054","post","type-post","status-publish","format-standard","hentry","category-staff-researches","tag-staff-researches"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/paQN8v-h0","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts\/1054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/comments?post=1054"}],"version-history":[{"count":1,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts\/1054\/revisions"}],"predecessor-version":[{"id":1055,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts\/1054\/revisions\/1055"}],"wp:attachment":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/media?parent=1054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/categories?post=1054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/tags?post=1054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}