{"id":1056,"date":"2019-04-14T09:08:08","date_gmt":"2019-04-14T09:08:08","guid":{"rendered":"https:\/\/albayan.edu.iq\/en\/?p=1056"},"modified":"2019-04-14T09:08:08","modified_gmt":"2019-04-14T09:08:08","slug":"synthesis-characterization-and-antimicrobial-evaluation-of-new-n-phenyl-cinnamaide-derivatives-linked-to-aspirin-and-ibuprofen","status":"publish","type":"post","link":"https:\/\/albayan.edu.iq\/en\/2019\/04\/14\/1056\/","title":{"rendered":"Synthesis, Characterization, and Antimicrobial Evaluation of New N-Phenyl Cinnamaide Derivatives Linked to Aspirin and Ibuprofen"},"content":{"rendered":"<p><span style=\"color: #ff0000;\"><strong>Assistant Lecturer Ameer Hussein Kadhim &amp; Assistant Lecturer Haider Jabbar Madloul<\/strong><\/span><\/p>\n<p><strong>Abstract <\/strong><\/p>\n<p><strong>Objective:<\/strong>The objective of this study was to synthesize phenylcinnamamide (substituted acetanilide chalcone) derivatives linked to aspirin and ibuprofen with potential antibacterial and antifungal activity.<\/p>\n<p><strong>Methods:<\/strong>Substituted acetanilide compounds were reacted with different arylaldehydes through Claisen-Schmidt condensation in the presence of KOH. They formed differently substituted acetanilide chalcones (1a-e) which are linked to aspirin and ibuprofen through an ester linkage to form compounds (2a-j) using ethyl chloroformate (ECF) as a catalyst.<\/p>\n<p><strong>Results:<\/strong>The synthesized compounds have been characterized by elemental analysis, Fourier transform infrared and1 H-nuclear magnetic resonance spectroscopy. An antibacterial evaluation was achieved for Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli) and antifungal for Candida albicans. Conclusion: Compounds (2a-j) have shown intermediate antimicrobial activity against different strains of microorganisms.<\/p>\n<p><strong>Keywords:<\/strong>Acetanilide, Claisen-Schmidt condensation, Chalcones, Aspirin, Ibuprofen, Antibacterial, Antifungal.<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/innovareacademics.in\/journals\/index.php\/ajpcr\/article\/view\/26937\/15836\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Link to Full Article<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Assistant Lecturer Ameer Hussein Kadhim &amp; Assistant Lecturer Haider Jabbar Madloul Abstract Objective:The objective of this study was to synthesize phenylcinnamamide (substituted acetanilide chalcone) derivatives linked to aspirin and ibuprofen with potential antibacterial and antifungal activity. Methods:Substituted acetanilide compounds were reacted with different arylaldehydes through Claisen-Schmidt condensation in the presence of KOH. They formed differently substituted acetanilide chalcones (1a-e) which are linked to aspirin and ibuprofen through an ester linkage to form compounds (2a-j) using ethyl chloroformate (ECF) as a catalyst. Results:The synthesized compounds have been characterized by elemental analysis, Fourier transform infrared and1 H-nuclear magnetic resonance spectroscopy. An antibacterial evaluation <a href=\"https:\/\/albayan.edu.iq\/en\/2019\/04\/14\/1056\/\"> [&#8230;]<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[26],"tags":[27],"class_list":["post-1056","post","type-post","status-publish","format-standard","hentry","category-staff-researches","tag-staff-researches"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/paQN8v-h2","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts\/1056","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/comments?post=1056"}],"version-history":[{"count":1,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts\/1056\/revisions"}],"predecessor-version":[{"id":1057,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts\/1056\/revisions\/1057"}],"wp:attachment":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/media?parent=1056"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/categories?post=1056"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/tags?post=1056"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}