{"id":1113,"date":"2019-04-22T07:19:39","date_gmt":"2019-04-22T07:19:39","guid":{"rendered":"https:\/\/albayan.edu.iq\/en\/?p=1113"},"modified":"2019-04-22T07:19:39","modified_gmt":"2019-04-22T07:19:39","slug":"sex-hormone-binding-globulin-level-in-male-patients-with-chronic-heart-failure","status":"publish","type":"post","link":"https:\/\/albayan.edu.iq\/en\/2019\/04\/22\/1113\/","title":{"rendered":"Sex Hormone-Binding Globulin Level in Male Patients with Chronic Heart Failure"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>Assistant Lecturer Adil A. Merza<\/strong><strong>\u00a0<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>Abstract:<\/strong><\/p>\n<p style=\"text-align: justify;\">Sex hormone-binding globulin (SHBG) is a key regulator of the actions of anabolic steroids. Chronic heart failure (HF) has been associated with anabolic steroid deficiency,<\/p>\n<p style=\"text-align: justify;\">The present study to assess the role of SHBG and sex hormones in patient with heart failure so as to it may be had importance for diagnostic and progression of heart failure.The study involved an 80 men (age range 45-69 years), 40 men had HF (i.e. left ventricular ejection fraction [LVEF] &lt;40%) and the other 40 men considered as the control group. The patients were selected from Ibn-Alnafis and Baghdad teaching hospitals. A blood sample was taken from each inclusion in the study via puncture of the antecubital vein, following a fasting period of at least 12 hours.The aliquots obtained were stored at -80\u00baC until analysis. Investigations included serum measurement of Sex Hormone-Binding Globulin (SHBG) ,FreeTestosterone(FT), TotalTestosterone(TT), Lutueinizin Hormone(LT) \u00a0and Follicle-Stimulating Hormone(FSH), were measured in a specific radioimmune analysis test ( Beckman Coulter, France, Czech Republic) with using Gamma Counter Instrument.<\/p>\n<p style=\"text-align: justify;\">The results showed high levels of SHBG hormone in patients with HF (41.46\u00b12.79) nM with a significant difference from that in the control group (33.23\u00b11.87) nM. A low levels were found for serum TT hormone in patients with HF (1.92\u00b10.188) ng\/ml with a significant difference from that in the control group (3.06\u00b10.26), also a low levels of FT hormone in patients with HF were found (6.20\u00b10.589) pg\/ml\u00a0 with a significant difference from that in the control group (8.07\u00b10.395) pg\/ml, the current study also showed that the values for the LH and FSH were within the normal range in the patient with HF ( LH 5.16\u00b10.59, FSH 5.18\u00b10.86) with no significant difference from that in the control group(LH 4.38\u00b10.26, FSH 4.33\u00b10.45) IU\/L.<\/p>\n<p style=\"text-align: justify;\">Measurement of the serum levels SHBG, FT, TT hormones is good diagnostic predictors in male patients with CHF.<\/p>\n<p style=\"text-align: justify;\"><strong><u>Key words<\/u><\/strong>: Sex hormone-binding globulin. Sex Hormones. Heart failure. Men.<\/p>\n<p style=\"text-align: justify;\"><strong>Full article is to be published in Journal of Al-Bayan University Issue 1, 2019.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Assistant Lecturer Adil A. Merza\u00a0 Abstract: Sex hormone-binding globulin (SHBG) is a key regulator of the actions of anabolic steroids. Chronic heart failure (HF) has been associated with anabolic steroid deficiency, The present study to assess the role of SHBG and sex hormones in patient with heart failure so as to it may be had importance for diagnostic and progression of heart failure.The study involved an 80 men (age range 45-69 years), 40 men had HF (i.e. left ventricular ejection fraction [LVEF] &lt;40%) and the other 40 men considered as the control group. The patients were selected from Ibn-Alnafis and Baghdad <a href=\"https:\/\/albayan.edu.iq\/en\/2019\/04\/22\/1113\/\"> [&#8230;]<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[26],"tags":[27],"class_list":["post-1113","post","type-post","status-publish","format-standard","hentry","category-staff-researches","tag-staff-researches"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/paQN8v-hX","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts\/1113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/comments?post=1113"}],"version-history":[{"count":1,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts\/1113\/revisions"}],"predecessor-version":[{"id":1114,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/posts\/1113\/revisions\/1114"}],"wp:attachment":[{"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/media?parent=1113"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/categories?post=1113"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/albayan.edu.iq\/en\/wp-json\/wp\/v2\/tags?post=1113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}