Prof. Intesar Tarik Numan
Abstract
The present study was designed to evaluate the nephroprotective effects of methanol extract of Artichoke as a comparative study with telmisartan against 5-FU induced nephrotoxicity in Wister rats. Thirty Wister rats were randomly divided into five groups: Ι, negative control receiving normal saline (2 ml/kg) orally for 14 successive days; ΙΙ, negative control receiving DMSO (2 ml/kg) orally for 14successive days; ΙΙΙ, positive control receiving normal saline (2ml/kg/day) orally for 14 days, and subsequently received 5- Fluorouracil (5-FU) (150mg in 2ml normal saline per kg body weight) ) single dose by intraperitoneal injection on the day 11; ΙѴ, receiving telmisartan (10mg/kg/day) for 14 successive days, and subsequently received 5-Fluorouracil (5-FU) (150mg in 2ml normal saline per kg body weight) ) single dose by intraperitoneal injection on the day 11; Ѵ, receiving Artichoke extract (400mg/kg/day) by oral intubation for 14 days, and subsequently received 5-Fluorouracil (5-FU) (150mg in 2ml normal saline per kg body weight) single dose by intraperitoneal injection on the day 11. Prophylactic treatment of Artichoke extract and telmisartan significantly attenuates the serum creatinine and blood urea nitrogen (BUN) elevation caused by 5-FU-induced nephrotoxicity, also, the histopathological study show the nephroprotective effects of methanol extract of Artichoke and telmisartan against 5-FU induced nephrotoxicity in Wister rats. Results of the present finding suggest that methanol extract of Artichoke and telmisartan may be a useful modulator in mitigating 5-FU induced nephrotoxicity.
Keywords:Artichoke extract, 5-FU, Telmisartan, Nephroprotective.
