Prof. Intesar Tarik Numan Abstract  The present study was designed to evaluate the nephroprotective effects of methanol extract of Artichoke as a comparative study with telmisartan against 5-FU induced nephrotoxicity in Wister rats. Thirty Wister rats were randomly divided into five groups: Ι, negative control receiving normal saline (2 ml/kg) orally for 14 successive days; ΙΙ, negative control receiving DMSO (2 ml/kg) orally for 14successive days; ΙΙΙ, positive control receiving normal saline (2ml/kg/day) orally for 14 days, and subsequently received 5- Fluorouracil (5-FU) (150mg in 2ml normal saline per kg body weight) ) single dose by intraperitoneal injection on the day [...]

Prof. Dr. Intesar Tarik Numan Abstract Background:Leukemia is a cancer of blood cells which treated by different anticancer agents, Plants nowadays considered a new source for the development of new anticancer agent. Euphorbia Lathyris use in folklore to treat skin cancer. Objective Euphorbia lathyris seeds phytochemically investigated then examined its cytotoxic activity against leukemia cells. Materials and Methods:Euphorbia lathyris seed was extracted by maceration with different organic solvents (petroleum ether, chloroform and methanol), each organic extract submitted to phytochemical investigation and evaluated its cytotoxic activity on Leukemic blood with three different doses (50,100 and 150 µg mLG1 ) and three different [...]